Products

PRONOVA
Ultra Pure Sodium Alginate USP/NF, EP

The Pronova product range is a family of highly purified, well characterized, biocompatible and biodegradable alginates, developed for use in biomedical and pharmaceutical applications. These products are available in two variants, Pronova UP (ultra pure) and Pronova SL (sterile), both having extremely low levels of endotoxins and proteins.

Alginates are linear copolymers with homopolymeric blocks of (1→4)-linked beta-D-mannuronate (M) and its C-5 epimer alpha-L-guluronate (G) residues respectively, covalently linked together in different sequences or blocks. Alternating M and G blocks form the most flexible chains which exhibit excellent solubility at lower pH.

The process of sterilizing alginate solutions may often be an obstacle due to polymer degradation during autoclaving or irradiation procedures. On the other hand, sterile filtration of highly viscous solutions may also be difficult. To overcome these problems, Pronova SL grades are introduced which are available in a sterilized and lyophilized form. Sterile aqueous solutions of sodium alginates can now be made by simply adding sterile water or buffers to Pronova SL and shaking the vial to facilitate its dissolution.

Grade

Type

Apparent Viscosity (mPa.s)

Monomer Content

Applications

Pronova UP VLVG

 

 

Ultra pure

 

< 20

Guluronate:

Min. 60%

 

In the development of novel drug delivery systems in the form of alginate beads for immobilization / encapsulation of living cells or other biomaterials and in the form of alginate foams and gels in areas such as tissue engineering, wound management, anti-adhesion, in-vivo / in-vitro cell support, medical implants and in-situ controlled release applications

Pronova UP LVG

20 - 200

Pronova UP MVG

> 200

Pronova UP VLVM

< 20

Mannuronate:

Min. 50%

 

Pronova UP LVM

20 - 200

Pronova UP MVM

> 200

Pronova SLG₂₀

Sterile

20 - 99

Guluronate:

Min. 60%

Pronova SLG₁₀₀

100 - 300

Pronova SLM₂₀

20 - 99

Mannuronate:

Min. 50%

Pronova SLM₁₀₀

100 - 300

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